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Chronic Methylphenidate Treatment During Early Life Is Associated with Greater Ethanol Intake in Socially Isolated Rats
Author(s) -
Gill Kathryn E.,
Chappell Ann M.,
Beveridge Thomas J. R.,
Porrino Linda J.,
Weiner Jeffrey L.
Publication year - 2014
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.12489
Subject(s) - methylphenidate , stimulant , anxiety , juvenile , population , psychology , saline , physiology , alcohol abuse , dopamine , medicine , psychiatry , attention deficit hyperactivity disorder , biology , environmental health , genetics
Background Methylphenidate ( MPH ) is a stimulant prescribed to treat attention‐deficit/ hyperactivity disorder. Its primary mechanism of action is in the dopamine system, alterations of which are associated with vulnerability to alcohol abuse. There are concerns that juvenile MPH treatment may influence adult drinking behavior. This study examined the interaction of MPH treatment and environmental rearing conditions, which are known to independently influence ethanol ( E t OH ) drinking behavior, on anxiety‐like behavior and vulnerability to alcohol abuse in a juvenile rodent model. Methods Male Sprague–Dawley rats were housed in enriched, standard, or isolated conditions for 4 weeks, starting at postnatal day 21. Rats were concurrently treated with 8 mg/kg/d MPH or saline, delivered via osmotic minipump. Anxiety‐like behavior was determined at the end of the treatment session, and 5 weeks later. After MPH treatment, rats were exposed to a 2‐bottle choice Et OH drinking procedure that lasted 3 weeks. Results Early life chronic MPH treatment was associated with greater Et OH intake and greater Et OH preference, but only in socially isolated animals. Isolated animals had greater levels of anxiety‐like behavior than standard‐housed or enriched animals after 4 weeks of exposure to the housing conditions, a difference that persisted even after all animals had been individually housed for an additional 5 weeks and exposed to Et OH . Conclusions These results suggest that early life MPH treatment may increase vulnerability to Et OH drinking in adulthood in a subset of the population. Additionally, this study highlights the importance of early rearing condition for establishing long‐lasting behavioral phenotypes. Environmental histories should be considered when prescribing MPH treatment to young children.