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Association Between HTR7 Genetic Polymorphisms and Alcohol Dependence, Using the Alcohol Use Disorders Identification Test (AUDIT)
Author(s) -
Kim JeongHyun,
Park ByungLae,
Cheong Hyun Sub,
Bae Joon Seol,
Kim Lyoung Hyo,
Kim Jee Wook,
Lee Byoung Chul,
Seo Cheong Hoon,
Kang TaeCheon,
Park SunHee,
Choi IhnGeun,
Shin Hyoung Doo
Publication year - 2014
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.12482
Subject(s) - alcohol use disorders identification test , alcohol dependence , single nucleotide polymorphism , alcohol , logistic regression , alcohol use disorder , medicine , serotonergic , haplotype , genome wide association study , genetic association , genotype , genetics , biology , serotonin , gene , receptor , alcohol consumption , biochemistry
Background A recent genome‐wide association study has identified 5‐hydroxytrytamine (serotonin) receptor 7, adenylate cyclase‐coupled ( HTR7 ) as a risk gene for alcohol dependence. In addition, the serotonergic system has been considered as a modulator that plays an important role in alcohol use disorders. Functional, pharmacological, and genetic studies of serotonin neurotransmission have revealed that serotonin receptors are potential targets for the treatment of alcohol use disorders. The aim of this study is to investigate whether associations between HTR7 genetic polymorphisms and alcohol dependence could be replicated. Methods This study genotyped a total of 22 common single nucleotide polymorphisms ( SNP s) in 459 alcoholic patients and 444 nonalcoholic controls. Results Logistic regression analysis of the case–control study, controlling for age and sex as covariates, showed nominal associations of 7 SNP s ( p = 0.02 to 0.04; odds ratio = 0.60 to 1.35). In further linear regression analysis based on the Alcohol Use Disorders Identification Test score for alcohol dependence, 8 SNP s and 3 haplotypes showed relatively significant associations with alcohol dependence (minimum p = 0.001; p corr = 0.02). Conclusions Although further replications and functional evaluations are needed, our findings suggest that genetic variations of HTR7 may contribute to the predisposition for alcohol dependence.