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Roles of the ALDH 2 and ADH 1B Genotypes on the Association Between Alcohol Intake and Serum Adiponectin Levels Among Japanese Male Workers
Author(s) -
Maeda Shinya,
Mure Kanae,
Mugitani Kouichi,
Watanabe Yutaka,
Iwane Masataka,
Mohara Osamu,
Takeshita Tatsuya
Publication year - 2014
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.12406
Subject(s) - adiponectin , aldh2 , adh1b , body mass index , medicine , endocrinology , alcohol , genotype , obesity , physiology , insulin resistance , biology , genetics , enzyme , biochemistry , gene , branched chain alpha keto acid dehydrogenase complex , dehydrogenase
Background Adiponectin secreted from adipose tissue is assumed to mediate protective effects on development of metabolic syndrome (MetS) and MetS‐related diseases such as cardiovascular diseases and cancer. Relationship between alcohol intake and circulating adiponectin levels is not consistent among the several previous studies. In the present study, we investigated effects of alcohol intake and the alcohol‐related polymorphisms on serum adiponectin levels among Japanese male workers. Methods We conducted a cross‐sectional design study with 541 male workers aged 51.5 ± 5.9 (mean ± SD ) years in a Japanese plant. Information on alcohol intake and other lifestyles was obtained by a self‐administered questionnaire. Serum total adiponectin (T‐Ad), high‐molecular‐weight adiponectin ( HMW ‐Ad), medium‐molecular‐weight adiponectin ( MMW ‐Ad), and low‐molecular‐weight adiponectin ( LMW ‐Ad) levels were measured by the enzyme‐linked immune assay system kit. Two genotypes in the alcohol dehydrogenase‐1B ( ADH1B ) and aldehyde dehydrogenase‐2 ( ALDH2 ) genes were determined using blood sample. In multivariate regression analyses, we adjusted for age, body mass index, smoking, and physical exercise. Results Among all subjects, high alcohol consumption of 12 units (1 unit contains 22.9 g of ethanol) a week or more was negatively associated with T‐Ad levels in the multivariate model, although not significant. When we performed analyses separately for each genotype, high alcohol consumption was negatively associated with T‐Ad, HMW ‐Ad, and LMW ‐Ad levels only in those with ADH 1B *2/*2 . Such relationships were not observed in each ALDH 2 genotype group. Conclusions High alcohol consumption was inversely associated with T‐Ad, HMW ‐Ad, and LMW ‐Ad levels in those with ADH 1B *2/*2 genotype, but not in those with the other ADH 1B genotypes. To our knowledge, this is the first study that reports combined effects of the alcohol‐related polymorphisms and alcohol intake on serum adiponectin levels. Additional studies are required to confirm the present finding.