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The Diagnostic Value of Serum Ischemia‐modified Albumin Levels in Experimentally Induced Carbon Monoxide Poisoning and Their Correlation With Poisoning Severity
Author(s) -
Turedi Suleyman,
Yilmaz Sennur Ekici,
Mentese Ahmet,
Turkmen Suha,
Karaca Yunus,
Sen Ozlem,
Yulug Esin,
Gunduz Abdulkadir
Publication year - 2013
Publication title -
academic emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 124
eISSN - 1553-2712
pISSN - 1069-6563
DOI - 10.1111/acem.12159
Subject(s) - ischemia modified albumin , carboxyhemoglobin , medicine , carbon monoxide poisoning , malondialdehyde , co poisoning , albumin , positive correlation , gastroenterology , serum albumin , anesthesia , ischemia , poison control , carbon monoxide , myocardial ischemia , oxidative stress , biochemistry , emergency medicine , chemistry , catalysis
Objectives The objectives were to determine the diagnostic value of blood ischemia‐modified albumin ( IMA ) levels in experimentally induced carbon monoxide ( CO ) poisoning and to analyze their correlation with poisoning severity. Methods Thirty‐six female rats were randomly assigned to one of three groups: I (control group), II (low‐dose CO poisoning group), and III (high‐dose CO poisoning group). The control group was kept in room air, while groups II and III were exposed to 3 L/min of 3,000 ppm and 3 L/min of 5,000 ppm CO gas for 30 minutes, respectively. Serum carboxyhemoglobin ( COH b), IMA , and malondialdehyde ( MDA ) levels; brain, heart, lung, liver, and kidney tissue MDA measurements; and histopathologic damage scores were then compared. Results IMA levels were significantly higher in groups II and III than in group I. A moderate positive correlation was observed between COH b and IMA levels. There was a strong positive correlation between COH b levels and degree of damage in all organs, but IMA and MDA levels did not reflect a similar correlation. Conclusions Ischemia‐modified albumin levels are higher in rats exposed to CO . This indicates that IMA levels can potentially be important in the diagnosis of exposure to CO or of CO poisoning. However, IMA levels are not a good biochemical marker in terms of determining the severity of poisoning.