Open AccessIdentification of aging‐associated immunotypes and immune stability as indicators of post‐vaccination immune activation
Author(s) -
Cevirgel Alper,
Shetty Sudarshan A.,
Vos Martijn,
Nanlohy Nening M.,
Beckers Lisa,
Bijvank Elske,
Rots Nynke,
Beek Josine,
Buisman AnneMarie,
Baarle Debbie
Publication year - 2022
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13703
Subject(s) - immune system , biology , immunosenescence , vaccination , immunology , population , medicine , environmental health
Immunosenescence describes immune dysfunction observed in older individuals. To identify individuals at‐risk for immune dysfunction, it is crucial to understand the diverse immune phenotypes and their intrinsic functional capabilities. We investigated immune cell subsets and variation in the aging population. We observed that inter‐individual immune variation was associated with age and cytomegalovirus seropositivity. Based on the similarities of immune subset composition among individuals, we identified nine immunotypes that displayed different aging‐associated immune signatures, which explained inter‐individual variation better than age. Additionally, we correlated the immune subset composition of individuals over approximately a year as a measure of stability of immune parameters. Immune stability was significantly lower in immunotypes that contained aging‐associated immune subsets and correlated with a circulating CD38 + CD4+ T follicular helper cell increase 7 days after influenza vaccination. In conclusion, immune stability is a feature of immunotypes and could be a potential indicator of post‐vaccination cellular kinetics.