Open AccessPlasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long‐lived individuals
Author(s) -
Siino Valentina,
Ali Ashfaq,
Accardi Giulia,
Aiello Anna,
Ligotti Mattia E.,
Mosquim Junior Sergio,
Candore Giuseppina,
Caruso Calogero,
Levander Fredrik,
Vasto Sonya
Publication year - 2022
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13684
Subject(s) - biology , fibulin , cohort , sicilian , proteome , genetics , bioinformatics , medicine , gene , linguistics , philosophy
The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well‐being and to possibly predict and/or avoid the development of age‐related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry‐based approach to study age‐related protein changes in a healthy Sicilian plasma cohort including long‐lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin‐1, dystroglycan, and gamma‐glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.