Open AccessHow does maternal age affect genomic stability in the offspring?
Author(s) -
Sturm Ádám,
Vellai Tibor
Publication year - 2022
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13612
Subject(s) - biology , offspring , zygote , transposable element , affect (linguistics) , genetics , oocyte , evolutionary biology , gene , genome , pregnancy , embryo , embryogenesis , linguistics , philosophy
In high‐income countries, women tend to give birth at increasingly advanced ages. Despite its physiological, developmental, and medical consequences, why this tendency significantly affects genetic stability of the offspring remains largely unresolved. Accumulating evidence indicates that the higher the age of the mother at fertilization, the more intense the activity of transposable elements causing insertional mutations in functional DNA stretches in her oocyte involved in zygote formation.