Open AccessTissue engineering strategies to bioengineer the ageing skin phenotype in vitro
Author(s) -
Costello Lydia,
Dicolandrea Teresa,
Tasseff Ryan,
Isfort Robert,
Bascom Charlie,
von Zglinicki Thomas,
Przyborski Stefan
Publication year - 2022
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13550
Subject(s) - ageing , phenotype , biology , healthy ageing , computational biology , microbiology and biotechnology , genetics , gene
Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro.