Open AccessEmerging rejuvenation strategies—Reducing the biological age
Author(s) -
Zhang Bohan,
Trapp Alexandre,
Kerepesi Csaba,
Gladyshev Vadim N.
Publication year - 2022
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13538
Subject(s) - rejuvenation , longevity , biology , psychological intervention , successful aging , intervention (counseling) , biological age , gerontology , psychology , evolutionary biology , medicine , genetics , psychiatry
Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti‐aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic reduction in biological age, which can be assessed by biomarkers of aging, such as epigenetic clocks. We discuss known and putative rejuvenation interventions and comparatively analyze them to explore underlying mechanisms.