Open AccessSulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling
Author(s) -
Bose Chhanda,
Alves Ines,
Singh Preeti,
Palade Philip T.,
Carvalho Eugenia,
Børsheim Elisabet,
Jun SeRan,
Cheema Amrita,
Boerma Marjan,
Awasthi Sanjay,
Singh Sharda P.
Publication year - 2020
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13261
Subject(s) - sulforaphane , skeletal muscle , sarcopenia , biology , myocyte , medicine , cardiac function curve , endocrinology , myopathy , oxidative stress , keap1 , heart failure , transcription factor , cancer research , biochemistry , genetics , gene
Scheme depicts hypothesized decreases of heart and SKM function during aging via ROS and partial reversal by SFN activation of Nrf2 that results in significant restoration of function of both types of muscle. A decline in heart and skeletal muscle function was observed in aged mice, with altered mitochondrial structure and gene expression, accompnied by decreases in mitochondrial complex activity, Nrf2 binding to antioxidant‐responsive DNA elements and physical endurance. The addition of sulforaphane (SFN) to the diet improved these age‐related changes in older mice to levels observed in younger ones. We demonstrated in this paper that SFN alleviates age‐associated oxidative damage and improves mitochondrial and cardiac function as well as physical endurance in old mice.