Open AccessCD8 + T cells are increased in the subventricular zone with physiological and pathological aging
Author(s) -
MorenoValladares Manuel,
MorenoCug Leire,
Silva Tulio Mateo,
Garcés Juan Pablo,
SaenzAntoñanzas Ander,
ÁlvarezSatta María,
Matheu Ander
Publication year - 2020
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.13198
Subject(s) - subventricular zone , infiltration (hvac) , biology , dentate gyrus , pathological , neural stem cell , cd8 , neuroscience , stem cell , pathology , immunology , microbiology and biotechnology , central nervous system , medicine , immune system , physics , thermodynamics
Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T‐cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3 + and CD8 + T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3 + and CD8 + T cells in the SVZ of individuals with neurodegenerative diseases. However, T‐cell count was similar when compared non‐neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non‐pathological conditions and also in neurodegenerative contexts.