Open AccessAge‐dependent changes and biomarkers of aging in Caenorhabditis elegans
Author(s) -
Son Heehwa G.,
Altintas Ozlem,
Kim Eun Ji E.,
Kwon Sujeong,
Lee SeungJae V.
Publication year - 2019
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12853
Subject(s) - caenorhabditis elegans , biology , model organism , microrna , gene , healthy aging , computational biology , genetics , gerontology , medicine
Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan, and clear age‐dependent physiological changes. Aged C. elegans display a decline in their anatomical and functional features, including tissue integrity, motility, learning and memory, and immunity. Caenorhabditis elegans also exhibit many age‐associated changes in the expression of microRNAs and stress‐responsive genes and in RNA and protein quality control systems. Many of these age‐associated changes provide information on the health of the animals and serve as valuable biomarkers for aging research. Here, we review the age‐dependent changes in C. elegans and their utility as aging biomarkers indicative of the physiological status of aging.