Open AccessAging and Alzheimer’s disease: Comparison and associations from molecular to system level
Author(s) -
Xia Xian,
Jiang Quanlong,
McDermott Joseph,
Han JingDong J.
Publication year - 2018
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12802
Subject(s) - disease , dementia , causality (physics) , alzheimer's disease , amyloid (mycology) , biology , biochemistry of alzheimer's disease , neuroscience , gerontology , amyloid precursor protein , medicine , physics , botany , quantum mechanics
Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.