Open AccessThe DrugAge database of aging‐related drugs
Author(s) -
Barardo Diogo,
Thornton Daniel,
Thoppil Harikrishnan,
Walsh Michael,
Sharifi Samim,
Ferreira Susana,
Anžič Andreja,
Fernandes Maria,
Monteiro Patrick,
Grum Tjaša,
Cordeiro Rui,
DeSouza Evandro Araújo,
Budovsky Arie,
Araujo Natali,
Gruber Jan,
Petrascheck Michael,
Fraifeld Vadim E.,
Zhavoronkov Alexander,
Moskalev Alexey,
Magalhães João Pedro
Publication year - 2017
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12585
Subject(s) - biology , longevity , computational biology , senescence , drug discovery , database , model organism , functional genomics , drug , gene , bioinformatics , genomics , genetics , pharmacology , genome , computer science
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.