Open AccessFunction of the SIRT 3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
Author(s) -
Ansari Aneesa,
Rahman Md. Shahedur,
Saha Subbroto K.,
Saikot Forhad K.,
Deep Akash,
Kim KiHyun
Publication year - 2017
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12538
Subject(s) - sirt3 , sirtuin , biology , acetylation , histone deacetylase , sirt2 , disease , amyotrophic lateral sclerosis , cancer , mitochondrion , histone , sirtuin 1 , histone deacetylase inhibitor , histone deacetylase 5 , sirt6 , bioinformatics , microbiology and biotechnology , genetics , gene , medicine , downregulation and upregulation
Summary In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT 3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT 3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes. SIRT 3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of SIRT 3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.