Open AccessCellular senescence impact on immune cell fate and function
Author(s) -
Vicente Rita,
MaussetBonnefont AnneLaure,
Jorgensen Christian,
LouisPlence Pascale,
Brondello JeanMarc
Publication year - 2016
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12455
Subject(s) - biology , senescence , immune system , microbiology and biotechnology , phenotype , cell , cellular senescence , homeostasis , immunology , lymphocyte , genetics , gene
Summary Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo . Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T‐lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T‐helper lymphocyte‐dependent tissue homeostatic functions and T‐regulatory cell‐dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide‐reaching role as a homeostatic orchestrator.