Open AccessThe life‐extending effect of dietary restriction requires F oxo3 in mice
Author(s) -
Shimokawa Isao,
Komatsu Toshimitsu,
Hayashi Nobutaka,
Kim SangEun,
Kawata Takuya,
Park Seongjoon,
Hayashi Hiroko,
Yamaza Haruyoshi,
Chiba Takuya,
Mori Ryoichi
Publication year - 2015
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12340
Subject(s) - foxo3 , foxo1 , biology , knockout mouse , transcription factor , medicine , endocrinology , cancer research , genetics , gene
Summary Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction ( DR ). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild‐type ( WT ) and Foxo3‐knockout heterozygous ( +/– ) and homozygous ( –/– ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum ( AL ) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3 +/– or Foxo3 –/– mice. However, DR reduced the prevalence of tumors at death in WT , Foxo3 +/– , and Foxo3 –/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR . The findings in Foxo3 +/– mice contrast with those in Foxo1 +/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.