Open AccessAccelerated epigenetic aging in Down syndrome
Author(s) -
Horvath Steve,
Garagnani Paolo,
Bacalini Maria Giulia,
Pirazzini Chiara,
Salvioli Stefano,
Gentilini Davide,
Di Blasio Anna Maria,
Giuliani Cristina,
Tung Spencer,
Vinters Harry V.,
Franceschi Claudio
Publication year - 2015
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12325
Subject(s) - epigenetics , trisomy , biology , down syndrome , premature aging , dna methylation , brain aging , epigenome , bioinformatics , physiology , genetics , neuroscience , gene , cognition , gene expression
Summary Down Syndrome ( DS ) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10 −14 ).