Open AccessThe influence of skeletal muscle on systemic aging and lifespan
Author(s) -
Demontis Fabio,
Piccirillo Rosanna,
Goldberg Alfred L.,
Perrimon Norbert
Publication year - 2013
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12126
Subject(s) - myokine , biology , skeletal muscle , disease , sarcopenia , bioinformatics , physiology , neuroscience , endocrinology , medicine
Summary Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age‐related diseases such as metabolic syndrome, cancer, A lzheimer's and P arkinson's disease. Here, we review recent studies in mammals and D rosophila highlighting how nutrient‐ and stress‐sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle‐derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age‐related diseases and contribute to the intertissue communication that underlies systemic aging.