Open AccessFOXO 4 is necessary for neural differentiation of human embryonic stem cells
Author(s) -
Vilchez David,
Boyer Leah,
Lutz Margaret,
Merkwirth Carsten,
Morantte Ianessa,
Tse Chris,
Spencer Brian,
Page Lesley,
Masliah Eliezer,
Berggren William Travis,
Gage Fred H.,
Dillin Andrew
Publication year - 2013
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/acel.12067
Subject(s) - proteostasis , biology , embryonic stem cell , microbiology and biotechnology , proteasome , transcription factor , autophagy , proteome , foxo3 , neural stem cell , stem cell , genetics , apoptosis , gene
Summary Proteostasis is critical for maintaining cell function and proteome stability may play an important role in human embryonic stem cell (h ESC ) immortality. Notably, h ESC populations exhibit a high assembly of active proteasomes, a key node of the proteostasis network. FOXO 4, an insulin/ IGF ‐1 responsive transcription factor, regulates proteasome activity in h ESC s. We find that loss of FOXO 4 reduces the potential of h ESC s to differentiate into neural lineages. Therefore, FOXO 4 crosses evolutionary boundaries and links h ESC function to invertebrate longevity modulation.