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Non‐sedation—Does it improve health‐related quality of life after critical illness? A 3‐month follow‐up sub‐study of the NONSEDA trial
Author(s) -
Olsen Hanne T.,
Nedergaard Helene K.,
Hough Catherine L.,
Korkmaz Serkan,
Jensen Hanne I.,
Strøm Thomas,
Toft Palle
Publication year - 2021
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13775
Subject(s) - medicine , sedation , critical illness , quality of life (healthcare) , intensive care medicine , medline , emergency medicine , critically ill , anesthesia , nursing , political science , law
Background Critical illness is associated with severely impaired health‐related quality of life (HRQoL) for years following discharge. The NONSEDA trial was a multicenter randomized trial on non‐sedation versus sedation with a daily wake‐up trial in critically ill, mechanically ventilated patients in Scandinavia. The aim of this sub‐study was to assess the effect of non‐sedation on HRQoL and degree of independence in activities in daily living (ADL) 3 months post‐ICU. Methods All survivors were asked to complete the Medical Outcomes Study Short‐Form 36 questionnaire (SF‐36) and the Barthel Index 3 months post‐ICU. To limit missing data, reminders were sent. If unsuccessful, telephone interviews could be used. Outcomes were the level of HRQoL and ADL‐function in each group. All outcomes were assessed blinded. Results Of the 700 patients included 412 survived to follow‐up. A total of 344 survivors participated (82%). Baseline data were equal between the two groups. Mean SF‐36 scores for the non‐sedated vs sedated patients were as follows: Physical Function 45 vs 40, P = .69, Bodily Pain: 61 vs 52, P = .81, General Health: 50 vs 50, P = .84, Vitality: 42 vs 44, P = .85, Social Function: 75 vs 63, P = .85, Role Emotional: 58 vs 50, P = .82, Mental Health: 70 vs 70, P = .89, Role Physical: 25 vs 28, P = .32, Physical Component Score: 38 vs 37, P = .81, Mental Component Score: 48 vs 46, P = .94, Barthel Index: 20 vs 20, P = .74. Conclusion Randomization to non‐sedation neither improved nor impaired health‐related quality of life or degree of independence in activities in daily living 3 months post‐ICU discharge.