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Effects of inhaled nitric oxide in COVID‐19–induced ARDS – Is it worthwhile?
Author(s) -
Lotz Christopher,
Muellenbach Ralf M.,
Meybohm Patrick,
Mutlak Haitham,
Lepper Philipp M.,
Rolfes CarolineBarbara,
Peivandi Asghar,
Stumpner Jan,
Kredel Markus,
Kranke Peter,
Torje Iuliu,
Reyher Christian
Publication year - 2021
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13757
Subject(s) - ards , medicine , oxygenation , nitric oxide , anesthesia , covid-19 , inhalation , ventilation (architecture) , acute respiratory distress , vascular resistance , hemodynamics , cardiology , lung , disease , infectious disease (medical specialty) , mechanical engineering , engineering
Background Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID‐19)–induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation. Methods We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID‐19 ARDS patients receiving 20 ppm iNO for 15‐30 minutes. Results The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed. Conclusion Overall, iNO could provide immediate help and delay respiratory deterioration in COVID‐19–induced moderate to severe ARDS.