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Ketamine for post‐operative pain treatment in spinal surgery. A protocol for a systematic review with meta‐analysis and trial sequential analysis
Author(s) -
Pind Alison Holten,
Laursen Christina Cleveland,
Andersen Cheme,
Maagaard Mathias,
Mathiesen Ole
Publication year - 2021
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13712
Subject(s) - medicine , ketamine , perioperative , meta analysis , placebo , clinical trial , systematic review , analgesic , medline , randomized controlled trial , protocol (science) , adverse effect , anesthesia , surgery , alternative medicine , pathology , political science , law
Background Post‐operative pain treatment with ketamine has been demonstrated to have post‐operative opioid‐sparing and anti‐hyperalgesic effects. However, evidence regarding the beneficial and harmful effects and the optimal dose and timing of perioperative treatment with ketamine for patients undergoing spinal surgery is unclear. The objective of this systematic review is to assess the analgesic, serious and non‐serious adverse effects of perioperative pain treatment with ketamine for patients undergoing spinal surgery. Methods This protocol for a systematic review is written according to The Preferred Reporting Items for Systematic Review and Meta‐Analysis Protocols guidelines. We will search Embase, CENTRAL, PubMed, WHO’s ICTRP, EU Clinical Trial Register and ClinicalTrials.gov to identify relevant randomised clinical trials. We will include all randomised clinical trials assessing perioperative ketamine treatment versus placebo or no intervention for patients undergoing spinal surgery. Two authors will independently screen trials for inclusion using Covidence, extract data and assess risk of bias using Cochrane's RoB tool. We will analyse data using Review Manager and Trial Sequential Analysis. Meta‐analysis will be performed according to the Cochrane guidelines and results will be validated according to the eight‐step procedure suggested by Jakobsen et al. We will present our primary findings in a ‘summary of findings’ table. We will evaluate the overall certainty of evidence using the GRADE approach. Discussion This systematic review will assess the beneficial and harmful effects of perioperative pain treatment with ketamine for patients undergoing spinal surgery and have the potential to inform best practice and advance research.