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The effect of preoperative anxiety on phenylephrine dose during cesarean delivery: An open controlled one‐arm clinical trial
Author(s) -
Da Eran,
Heesen Philip,
OrbachZinger Sharon,
Kornilov Evgeniya,
Ronen Ariel,
Weiniger Carolyn,
Eidelman Leonid
Publication year - 2020
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13683
Subject(s) - medicine , phenylephrine , anesthesia , anxiety , spinal anesthesia , anesthesiology , blood pressure , psychiatry
Background We performed an open controlled one‐arm clinical trial to assess whether preoperative anxiety influences phenylephrine dosage required to maintain normotension during cesarean section under spinal anesthesia. Methods Ninety‐four parturients undergoing elective cesarean delivery under spinal anesthesia were included. Anxiety levels were measured using a verbal numerical scale anxiety score (0‐10). Phenylephrine infusion to prevent hypotension was adjusted by a standard algorithm. The primary outcome was total phenylephrine dose. Linear uni‐ and multivariate regressions were performed to assess the relationship between preoperative anxiety and the outcome. P < .05 was considered statistically significant. Results We found no association between preoperative anxiety and phenylephrine dosage ( R 2 = 0.05). Taking the number of attempts for spinal anesthesia and surgical time into account did not lead to a significant improvement of the regression model. Conclusion In conclusion, we did not find a large independent effect of preoperative anxiety on phenylephrine dose required to maintain normotension in our cohort. We believe that spinal hypotension and phenylephrine dose requirement are multifactorial and anxiety is only one of the factors in this complex interaction.