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Treatment strategies for new‐onset atrial fibrillation in critically ill patients: Protocol for a systematic review
Author(s) -
Wetterslev Mik,
Granholm Anders,
Haase Nicolai,
Hassager Christian,
Hylander Møller Morten,
Perner Anders
Publication year - 2020
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13672
Subject(s) - medicine , intensive care medicine , atrial fibrillation , medline , psychological intervention , cochrane library , randomized controlled trial , systematic review , meta analysis , critically ill , placebo , adverse effect , alternative medicine , psychiatry , pathology , political science , law
Background New‐onset atrial fibrillation is frequent in critically ill patients and associated with poorer outcomes in these patients. Numerous interventions are used for the management of new‐onset atrial fibrillation, but it is unknown if these interventions improve patient‐important outcomes as compared with placebo or no active intervention in adult critically ill patients. Methods/design We will conduct a systematic review with meta‐analysis and trial sequential analysis of randomized clinical trials assessing pharmacological and non‐pharmacological interventions of new‐onset atrial fibrillation as compared with placebo or no active intervention in adult critically ill patients. The primary outcomes are mortality, adverse events and health‐related quality of life. We will search the following databases: MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, Science Citation Index and BIOSIS and follow the recommendations by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines. We will evaluate the overall certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Discussion New‐onset atrial fibrillation is common in adult critically ill patients. However, the balance between the desirable and undesirable effects of pharmacological and non‐pharmacological interventions is unknown. The outlined systematic review aims to provide updated data on this topic. Registration Submitted to PROSPERO (CRD42020187178 ). Status: accepted.