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Oxycodone for pain management in the latent phase of labour – A pragmatic trial
Author(s) -
Kinnunen Mari,
Kokki Hannu,
Hautajärvi Heidi,
Tuovinen Kaisa,
Kokki Merja
Publication year - 2020
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13550
Subject(s) - oxycodone , medicine , oxymorphone , anesthesia , adverse effect , context (archaeology) , apgar score , opioid , pregnancy , birth weight , paleontology , genetics , receptor , biology
Background Parenteral opioids are used for pain relief in labour but there are little data for oxycodone in this context. The aim of this study was to evaluate the efficacy, foetal exposure and safety of subcutaneous oxycodone in the latent phase of labour. Methods This pragmatic trial included 76 parturients, who received subcutaneous oxycodone for pain relief in the latent phase of labour according to the hospital protocol: an initial dose 0.1 mg/kg, and a second dose, 0.05 mg/kg, could be administered four hours later. Pain intensity and pain relief were assessed using a numerical rating scale of 0‐10. After delivery, blood samples from the maternal and umbilical veins were collected, and plasma concentrations of oxycodone and its main metabolites were quantified using UPLC‐MS/MS. The Apgar scores and maternal and neonatal adverse effects were recorded. Results The foetal exposure at birth was low, the median oxycodone and oxymorphone umbilical vein plasma concentrations were 1.2 ng/mL (range 0.21‐7.8) and 0.14 ng/mL (0‐0.26), respectively. Pain scores decreased substantially, from a median pain score of 7/10 before oxycodone to median scores of 5/10 at 30 minutes after administration, 5/10 at 60 minutes and 6/10 at 120 minutes. The median Apgar score was 9 (range 2‐10) at 1 minute and 9 (6‐10) at 5 minutes. Maternal adverse effects were mild, and there were no oxycodone‐related neonatal adverse effects. Conclusion Subcutaneous oxycodone provided effective analgesia during the latent phase of labour. Newborn exposure at birth was low, and oxycodone was well‐tolerated.