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CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil
Author(s) -
Lv J.,
Liu F.,
Feng N.,
Sun X.,
Tang J.,
Xie L.,
Wang Y.
Publication year - 2018
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13178
Subject(s) - sufentanil , medicine , cyp3a4 , alfentanil , anesthesia , remifentanil , analgesic , fentanyl , genotype , polymorphism (computer science) , allele , gene , metabolism , genetics , cytochrome p450 , biology , propofol
Background Pain is one of the major adverse clinical outcomes of cesarean section (CS). In the past few years, researchers and physicians have been optimizing post‐operative analgesic modalities, but the results are still undesirable for the parturient. The cytochrome P‐450 3A4 (CYP3A4) gene has been reported to contribute significantly to human liver microsomal oxidation of sufentanil and alfentanil. Methods We detected the frequency of CYP3A4 mutant allele, which is associated with the metabolism of diverse drugs, including opioids used for anesthesia. We then investigated the correlation between sufentanil (an opioid analgesic) consumption and CYP3A4 genetic polymorphism. Results We found the frequency of the CYP3A4∗1G (the mutant form of CYP3A) variant allele to be 0.279 in 71 parturients undergoing cesarean section and 137 age‐matched parturients with vaginal delivery. Interestingly, the parturients with homozygous CYP3A4∗1G showed less sufentanil consumption compared with those having the wild‐type genotype. Conclusion In summary, we found a correlation between CYP3A4 genetic polymorphism and sufentanil consumption. This might be helpful for optimizing the anesthesia strategies and reducing their side effects.