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Pre‐operative haemodynamic monitoring and resuscitation in hip fracture patients: Protocol for a prospective observational study
Author(s) -
Agerskov M.,
Sørensen H.,
Højlund J.,
Secher N. H.,
Foss N. B.
Publication year - 2018
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13163
Subject(s) - medicine , resuscitation , hemodynamics , context (archaeology) , perfusion , blood volume , cerebral perfusion pressure , hip fracture , observational study , stroke (engine) , peripheral , prospective cohort study , anesthesia , surgery , cardiology , mechanical engineering , paleontology , osteoporosis , engineering , biology
Background In a frail patient group often suffering from dehydration, hip fracture is potentially fatal partly because of the blood loss and thus deteriorated circulation. An important goal for haemodynamic monitoring and resuscitation is early detection of insufficient tissue perfusion. “The peripheral perfusion index” reflects changes in peripheral perfusion and blood volume. We hypothesize that hip fracture patients are hypovolaemic with poor peripheral perfusion and accordingly respond to controlled fluid resuscitation. The peripheral perfusion index might reflect restricted tissue perfusion in spite of stable central haemodynamic variables. Methods This prospective observational study assess to what extend hip fracture patients suffer from hypovolaemia and respond to a stroke volume‐guided fluid challenge. The secondary objectives are to evaluate correlation between the non‐invasive peripheral perfusion index and minimally invasive measures of stroke volume, changes in blood volume and near‐infrared spectroscopy determined tissue‐ and cerebral oxygenation and to compare results to prevalence of post‐operative complications including mortality. We will include 50 patients (>65 years) presenting a hip fracture and treated in a multimodal fast‐track regimen when written informed consent is available. Discussion This is likely the first study to address pre‐operative haemodynamic monitoring and resuscitation in hip fracture patients where adequate resuscitation is easily missed. We aim to evaluate feasibility of pre‐operative stroke volume‐guided haemodynamic optimization in the context of minimally‐ and non‐invasive monitoring of peripheral perfusion and measure of blood volume.