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Haloperidol for delirium in critically ill patients – protocol for a systematic review
Author(s) -
Barbateskovic M.,
Kraus S. R.,
Collet M. O.,
Mathiesen O.,
Jakobsen J. C.,
Perner A.,
Wetterslev J.
Publication year - 2018
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.13088
Subject(s) - delirium , medicine , cochrane library , medline , intensive care medicine , systematic review , randomized controlled trial , critical appraisal , haloperidol , clinical trial , intensive care unit , protocol (science) , placebo , meta analysis , psychiatry , alternative medicine , pathology , political science , dopamine , law
Background In the intensive care unit, the prevalence of delirium is high. Delirium has been associated with morbidity and mortality including more ventilator days, longer intensive care unit stay, increased long‐term mortality, and cognitive impairment. Thus, the burden of delirium for patients, relatives, and societies is considerable. The objective of this systematic review was to critically access the evidence of randomised clinical trials on the effects of haloperidol vs. placebo or any other agents for delirium in critically ill patients. Methods We will search for randomised clinical trials in the following databases: Cochrane Library, MEDLINE , EMBASE , Science Citation Index, BIOSIS , Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature, and Allied and Complementary Medicine Database. Two authors will independently screen and select references for inclusion using Covidence, extract data and assess the methodological quality of the included randomised clinical trials using the Cochrane risk of bias tool. Any disagreement will be resolved by consensus. We will analyse the extracted data using Review Manager, STATA 15, and Trial Sequential. Analysis The aim of this study was to assess the quality of the evidence, we will create a ‘Summary of Findings’ table containing our primary and secondary outcomes using the GRADE assessment. Discussion Our ambition with this systematic review is to provide reliable and powered evidence to better inform decision makers on the use of or future trials with haloperidol for the management of delirium in critically ill patients.