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Endothelial dysfunction after non‐cardiac surgery: a systematic review
Author(s) -
SØNDERGAARD E. S.,
FONNES S.,
GÖGENUR I.
Publication year - 2015
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.12426
Subject(s) - medicine , endothelial dysfunction , cardiac surgery , endothelium , cardiology , surgery
Background More than 50% of patients with increased troponin levels after non‐cardiac surgery have an impaired endothelial function pre‐operatively. Non‐invasive markers of endothelial function have been developed for the assessment of endothelial dysfunction. The aim of this paper was to systematically review the literature to evaluate the association between non‐cardiac surgery and non‐invasive markers of endothelial function. Methods A systematic search was conducted in MEDLINE , EMBASE and C ochrane L ibrary D atabase according to the PRISMA guidelines. Endothelial dysfunction was described only with non‐invasive measurements done both pre‐ and post‐operatively and published in E nglish. All types of non‐cardiac surgery and both men and women of all ages were included. Results We found 1722 eligible studies in our search, and of these, five studies fulfilled our inclusion and exclusion criteria. Endothelial function was disturbed in patients after non‐cardiac surgery. Three studies found a significant decrease in the endothelial function immediately after surgery (2 and 24 h post‐operatively). Two studies found that patients with previous endothelial dysfunction and scheduled for surgery (renal transplantation and vascular surgery respectively) had an improvement in endothelial dysfunction 1 month after surgery. Conclusion Endothelial function changes in relation to surgery. Assessment of endothelial function by non‐invasive measures has the potential to guide clinicians in the prevention or treatment of post‐operative myocardial damage.