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A nalgesia N ociception I ndex ( ANI ) to predict intraoperative haemodynamic changes: results of a pilot investigation
Author(s) -
LEDOWSKI T.,
AVERHOFF L.,
TIONG W. S.,
LEE C.
Publication year - 2014
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.12216
Subject(s) - medicine , nociception , anesthesia , hemodynamics , heart rate , fentanyl , blood pressure , sevoflurane , mean arterial pressure , cardiac index , stimulation , cardiac output , receptor
Background The A nalgesia N ociception I ndex has been described to reflect different levels of intraoperative nociceptive stimulation during total intravenous anaesthesia. The association between this index and haemodynamic changes during sevoflurane‐based anaesthesia was investigated in 30 patients with the hypothesis that changes in the A nalgesia N ociception I ndex may coincide with or even predict haemodynamic changes. Methods The A nalgesia N ociception I ndex as well as blood pressure and heart rate were observed during induction, at skin incision, at times of an A nalgesia N oceception I ndex decrease > 20% (‘event’) and pre‐/post‐fentanyl administration. Results The A nalgesia N ociception I ndex decreased with airway manipulation [mean: 52 (before) vs. 33 (after); P < 0.005] and after skin incision [mean: 63 (before) vs. 38 (after); P < 0.001], and it increased after fentanyl administration [53 (before) vs. 59 (after); P < 0.05]. However, its predictive probability to indicate heart rate and blood pressure increases of >10% was low (heart rate 0.61; blood pressure 0.59). Conclusions The A nalgesia N ociception I ndex appears to reflect different levels of stimulation during sevoflurane‐based general anaesthesia. However, it was of little predictive value to pre‐empt significant haemodynamic changes.