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Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol
Author(s) -
SONG JC.,
ZHANG MZ.,
WU QC.,
LU ZJ.,
SUN YM.,
YANG LQ.,
YU WF.
Publication year - 2013
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/aas.12085
Subject(s) - sevoflurane , medicine , blood urea nitrogen , propofol , creatinine , renal function , anesthesia , adverse effect , liver function , urology , gastroenterology , surgery
Background Cirrhotic patients are prone to developing renal dysfunction after anaesthesia and surgery. However, no consensus has been reached whether sevoflurane could have adverse effects on renal function in cirrhotic patients. We hypothesised that the use of sevoflurane for general anaesthesia would lead to post‐operative renal dysfunction in cirrhotic patients undergoing liver resection. Methods A total of 200 patients undergoing liver resection were randomly assigned to a propofol or sevoflurane group. The influence of sevoflurane or propofol on renal function was evaluated by the maximal change, the difference between the pre‐operative baseline and the highest values of serum creatinine and blood urea nitrogen measured at day 1, 3 and 6 post‐operatively. Results The maximal change in serum creatinine after liver resection was −4.52 (5.78) μmol/l and −3.37 (7.34) μmol/l with P = 0.398, and that in blood urea nitrogen was 0.41 (1.49) mmol/l and 0.93 (1.54) mmol/l with P = 0.098 between the sevoflurane group ( n = 52) and the propofol group ( n = 50), respectively. Conclusions Sevoflurane does not seem to impair post‐operative renal function in cirrhotic patients undergoing liver resection.