Open AccessMediastinal undifferentiated pleomorphic sarcoma with pleural effusion cytopathologically misdiagnosed as epithelial malignant pleural mesothelioma: An autopsy case report
Author(s) -
Matsumoto Kinnosuke,
Nakamura Yukihiro,
Inagaki Yuji,
Taniguchi Yoshihiko,
Tamiya Akihiro,
Matsuda Yoshinobu,
Kasai Takahiko,
Atagi Shinji
Publication year - 2021
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13898
Subject(s) - medicine , mesothelioma , pleural effusion , pathology , autopsy , malignant pleural effusion , pleural disease , biopsy , pathological , sarcoma , mediastinal tumor , radiology , mediastinum , respiratory disease , lung
Undifferentiated pleomorphic sarcoma (UPS) is a new disease in the World Health Organization's classification of tumors of soft tissue and bone published in 2013. Primary mediastinal UPS is rare, especially with pleural effusion. Herein, we describe the pathological findings of pleural effusion followed by mediastinal UPS, which was initially misdiagnosed as epithelial malignant pleural mesothelioma (MPM). The cytopathological findings of the pleural effusion cell block often contribute to the diagnosis of various malignant tumors. However, these findings may lead to misdiagnosis of highly invasive mediastinal tumors such as UPS. A biopsy for primary mediastinal lesions should be performed because MPM rarely mimics mediastinal tumors with pleural effusion.