Open AccessChemotherapy combined with bevacizumab for the treatment of advanced lung adenocarcinoma cancer harboring EGFR‐ANXA2, EGFR‐RAD51, ATR and BRCA2 mutations: A case report
Author(s) -
Zhong Rui,
Li Hui,
Liu Yanling,
Zhang Shuang,
Liu Jingjing,
Huang Zhicheng,
Cheng Ying
Publication year - 2020
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13286
Subject(s) - medicine , bevacizumab , pemetrexed , lung cancer , cancer research , exon , adenocarcinoma , chemotherapy , oncology , mutation , cancer , gene , cisplatin , biology , genetics
Here, we report a case of a 36‐year‐old female patient with metastatic non‐small cell lung cancer (NSCLC) harboring EGFR‐ANXA2 and EGFR‐RAD51 double fusion mutations with BRCA2 (nonsense mutation of exon 11) and ATR mutations (Exon 44 variable shear mutation) identified by next generation sequencing (NGS). The efficacy was significantly improved after lobaplatin combined with pemetrexed, temozolomide and bevacizumab. This is the first report of a novel mutation type EGFR‐ANXA2, as well as double EGFR fusion mutations in advanced lung adenocarcinoma. Furthermore, platinum‐based chemotherapy plus bevacizumab rather than targeted therapy showed favorable effects in this patient, providing a novel therapeutic conception for patients, even with multidriver mutations.