Open AccessDecoding tumor mutation burden and driver mutations in early stage lung adenocarcinoma using CT‐based radiomics signature
Author(s) -
Wang Xiaoxiao,
Kong Cheng,
Xu Weizhang,
Yang Sheng,
Shi Dan,
Zhang Jingyuan,
Du Mulong,
Wang Siwei,
Bai Yongkang,
Zhang Te,
Chen Zeng,
Ma Zhifei,
Wang Jie,
Dong Gaochao,
Sun Mengting,
Yin Rong,
Chen Feng
Publication year - 2019
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13163
Subject(s) - medicine , radiomics , adenocarcinoma , lung cancer , oncology , stage (stratigraphy) , cohort , pathological , germline mutation , biomarker , mutation , cancer , radiology , gene , paleontology , biochemistry , chemistry , biology
Background Tumor mutation burden (TMB) is an important determinant and biomarker for response of targeted therapy and prognosis in patients with lung cancer. The present study aimed to determine whether radiomics signature could non‐invasively predict the TMB status and driver mutations in patients with resectable early stage lung adenocarcinoma (LUAD). Methods A total of 61pulmonary nodules (PNs) from 51 patients post‐operatively diagnosed LUAD were enrolled for analysis. Two datasets were divided according to two‐thirds of patients from different commercial Comprehensive Genomic Profiling (CGP) panels: a training cohort including 41 PNs and a testing cohort including rest 20PNs. We sequenced all tumor specimens and paired blood cells using next generation sequencing (NGS), so as to detect TMB status and somatic mutations. We collected 718 quantitative 3D radiomics features extracted from segmented volumes of each PNs and 78 clinical and pathological features retrieved from medical records as well. Support vector machine methods were performed to establish the predictive model. Results We established an efficient fusion‐positive tumor prediction model that predicts TMB status and EGFR/TP53 mutations of early stage LUAD. The radiomics signature yielded a median AUC value of 0.606, 0.604, and 0.586 respectively. Combining radiomics with the clinical information can further improve the prediction performance, which the median AUC values are 0.671 for TMB, 0.697 and 0.656 for EGFR/TP53 respectively. Conclusion It is feasible and effective to facilitate TMB and somatic driver mutations prediction by using the radiomics signature and NGS data in early stage LUAD.