Open AccessDielectric properties for non‐invasive detection of normal, benign, and malignant breast tissues using microwave theories
Author(s) -
Cheng Yiou,
Fu Minghuan
Publication year - 2018
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12605
Subject(s) - breast cancer , medicine , microwave , permittivity , cancer , histology , dielectric , pathology , oncology , materials science , optoelectronics , physics , quantum mechanics
Background Despite the high incidence of breast cancer worldwide, methods for early non‐invasive diagnosis and sensitive and specific prognostic evaluation remain difficult. In this study, we investigated microwave parameters as a potential non‐invasive approach to detect breast cancer. Methods Samples of freshly excised breast tissues ( n = 509) from 98 patients were identified as normal, benign tumor, or malignant cancer via histology. Further samples were prepared and the microwave effective dielectric permittivity and effective conductivity were measured every 0.0375 GHz from 0.5 GHz to 8 GHz. These parameters were compared among the breast tissue types. Results The effective relative permittivity and effective conductivity at each frequency was significantly higher in breast cancer tissues compared with benign tumors, which in turn was significantly higher than in normal breast tissue. The standard deviation of each parameter was narrowest at ~2.5 GHz in both normal and malignant breast tissues. Conclusions The effective dielectric permittivity and effective conductivity, measured via microwave technology, could differentiate breast cancer from normal and benign tumor tissues.