Open AccessDifferent EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report
Author(s) -
Sakai Hiroki,
Saji Hisashi,
Kimura Hiroyuki,
Tsuda Masataka,
Wakiyama Yoichi,
Miyazawa Tomoyuki,
Marushima Hideki,
Kojima Koji,
Hoshikawa Masahiro,
Takagi Masayuki,
Nakamura Haruhiko
Publication year - 2018
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12554
Subject(s) - exon , adenocarcinoma , medicine , pathological , point mutation , lung cancer , mutation , lung , gene , cancer research , adenocarcinoma of the lung , pathology , gene mutation , oncology , cancer , genetics , biology
Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors.