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Background  This study examined the expression of exchange protein directly activated by c AMP 1 ( E pac1),  PDE 4, and  PKC  in esophageal cancer tissues, and analyzed the association of each protein with the pathological parameters of the samples.    Methods  Epac1,  PDE 4, and  PKC  protein expression was evaluated by  PV ‐9000 two‐step immunohistochemical techniques in 51 esophageal cancer specimens and 10 para‐carcinoma tissues.    Results  The positive expression rates of  E pac1 and  PKC  in esophageal cancer tissues (62.7% and 68.6%, respectively) were higher compared to those in para‐carcinoma tissues (20% and 20%, respectively) (  P   < 0.05). The positive expression rate of  PDE 4 in esophageal cancer tissues (54.1%) was higher than in para‐carcinoma tissues (30%), ( P  > 0.05).  E pac1,  PDE 4, and  PKC protein  expression levels were not associated with the extent of tumor differentiation and/or lymph node metastasis (  P   > 0.05).  E pac1 protein expression levels correlated with  PDE 4,  PKC,  and  AKA P95 protein expression levels. In addition, there was a correlation between  PKC  and  C x43 protein levels (  P   < 0.05).    Conclusion  The expression rates of  E pac1,  PDE 4, and  PKC  protein in esophageal cancer tissues were significantly higher compared to the rates in para‐carcinoma tissues, suggesting an association between these proteins and the development and progression of esophageal cancer. The correlations between these proteins also revealed that they may exert a synergistic effect during the development of esophageal cancer.

E pac1, PDE 4, and PKC protein expression and their correlation with AKAP 95 and C x43 in esophagus cancer tissues