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Background  The promoter region of the adenomatous polyposis coli ( APC ) gene is hypermethylated in several types of cancers, including non‐small cell lung cancer ( NSCLC ). The prevalence of methylation in the promoter region of this gene in tumor tissues and autologous controls has not been consistent in previous studies. We evaluated the frequency of  APC  gene promoter 1 A  methylation between tumor tissues and autologous controls in  NSCLC  patients by meta‐analysis.    Methods  Open published studies of  APC  gene promoter 1 A  methylation between tumor tissues and autologous samples in  NSCLC  patients were identified using a systematic search. Odds ratios ( OR ) and 95% confidence intervals ( CI ) of  APC  gene promoter 1 A  methylation in lung cancer tissues versus autologous controls were calculated. Fourteen studies, involving a total of 1345 patients and 2182 samples, were finally included.    Results  The pooled proportion of  APC  promoter 1 A  methylation was 0.62 (95%  CI  0.52–072) and 0.34 (95%  CI  0.21–0.50) in cancer tissues and autologous controls, respectively. The  APC  gene promoter 1 A  methylation rate in cancer tissues was much higher than in autologous controls, with a pooled  OR  of 3.66 (95%  CI  2.12–6.33). A strong and significant correlation of  APC  gene promoter 1 A  methylation between tumor tissues and autologous controls was detected (correlation coefficient r pearson  = 0.77;   P   = 0.0013).    Conclusion  The proportion of  APC  promoter 1 A  methylation in lung cancer tissues was higher than in autologous controls, indicating that promoter 1 A  methylation of the  APC  gene may play an important role in  NSCLC  carcinogenesis.

Does adenomatous polyposis coli gene promoter 1 A methylation increase non‐small cell lung cancer risk? A meta‐analysis