Open AccessDoes adenomatous polyposis coli gene promoter 1 A methylation increase non‐small cell lung cancer risk? A meta‐analysis
Author(s) -
Hu Baoli,
Zhang Hangfeng,
Wei Haitao,
Wang Zuopei,
Zhang Feng,
Wang Xiaolong,
Li Li
Publication year - 2017
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12450
Subject(s) - methylation , lung cancer , carcinogenesis , promoter , dna methylation , adenomatous polyposis coli , cancer research , medicine , gene , cancer , microbiology and biotechnology , colorectal cancer , biology , oncology , gene expression , genetics
Background The promoter region of the adenomatous polyposis coli ( APC ) gene is hypermethylated in several types of cancers, including non‐small cell lung cancer ( NSCLC ). The prevalence of methylation in the promoter region of this gene in tumor tissues and autologous controls has not been consistent in previous studies. We evaluated the frequency of APC gene promoter 1 A methylation between tumor tissues and autologous controls in NSCLC patients by meta‐analysis. Methods Open published studies of APC gene promoter 1 A methylation between tumor tissues and autologous samples in NSCLC patients were identified using a systematic search. Odds ratios ( OR ) and 95% confidence intervals ( CI ) of APC gene promoter 1 A methylation in lung cancer tissues versus autologous controls were calculated. Fourteen studies, involving a total of 1345 patients and 2182 samples, were finally included. Results The pooled proportion of APC promoter 1 A methylation was 0.62 (95% CI 0.52–072) and 0.34 (95% CI 0.21–0.50) in cancer tissues and autologous controls, respectively. The APC gene promoter 1 A methylation rate in cancer tissues was much higher than in autologous controls, with a pooled OR of 3.66 (95% CI 2.12–6.33). A strong and significant correlation of APC gene promoter 1 A methylation between tumor tissues and autologous controls was detected (correlation coefficient r pearson = 0.77; P = 0.0013). Conclusion The proportion of APC promoter 1 A methylation in lung cancer tissues was higher than in autologous controls, indicating that promoter 1 A methylation of the APC gene may play an important role in NSCLC carcinogenesis.