Open AccessHigh expression of long non‐coding HOX antisense transcript RNA and its clinical significance in cancer tissues: A meta‐analysis
Author(s) -
Wang Lei,
Zhao Yandong,
Qin Yi,
Xuan Yunpeng,
Qiu Tong,
Fu Bo,
Ren Xiaoyang,
Jiao Wenjie
Publication year - 2017
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12435
Subject(s) - hotair , medicine , long non coding rna , odds ratio , hox gene , metastasis , cancer , confidence interval , meta analysis , rna , cancer research , oncology , pathology , gene expression , gene , biology , genetics
Background HOX antisense transcript RNA (HOTAIR) is a 2148 nt long, intergenic, non‐coding RNA molecule, which is reported to be highly expressed in many types of cancers. This meta‐analysis summarizes its expression in cancer. Methods We searched all eligible papers on the prognostic impact of HOTAIR in cancer from inception to 30 S eptember 2015 in P ub M ed, CBM disc, and the CNK I database. Only full texts were included. R evman 5.3 was used for m eta‐analysis. Results A total of 11 studies of 1010 cases were included in the meta‐analysis. HOTAIR expression was higher in: cancer tissues in than adjacent or normal tissues (odds ratio [ OR] 37.52, 95% confidence interval [ CI] 18.94–74.31; P < 0.00001); in cancer tissues with lymph node metastasis than in those without lymph node metastasis ( OR 3.37, 95% CI 2.36–4.82; P < 0.00001); and in histological grades II–III than in histological grade I ( OR 0.47, 95% CI 0.29–0.75; P = 0.002). Conclusion This study shows that HOTAIR may play an important role in cancer occurrence and development, but whether it is a marker of cancer diagnosis and reliable prognosis remains to be confirmed. More rigorous design and meticulous quality epidemiological studies are required.