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Background  HOX antisense transcript RNA  (HOTAIR)  is a 2148 nt long, intergenic, non‐coding  RNA  molecule, which is reported to be highly expressed in many types of cancers. This meta‐analysis summarizes its expression in cancer.    Methods  We searched all eligible papers on the prognostic impact of  HOTAIR  in cancer from inception to 30  S eptember 2015 in  P ub M ed,  CBM disc, and the  CNK I database. Only full texts were included.  R evman 5.3 was used for  m eta‐analysis.    Results  A total of 11 studies of 1010 cases were included in the meta‐analysis.  HOTAIR  expression was higher in: cancer tissues in than adjacent or normal tissues (odds ratio [ OR]  37.52, 95% confidence interval [ CI]  18.94–74.31;   P   < 0.00001); in cancer tissues with lymph node metastasis than in those without lymph node metastasis ( OR  3.37, 95%  CI  2.36–4.82;   P   < 0.00001); and in histological grades II–III than in histological grade I ( OR  0.47, 95%  CI  0.29–0.75;   P   = 0.002).    Conclusion  This study shows that  HOTAIR  may play an important role in cancer occurrence and development, but whether it is a marker of cancer diagnosis and reliable prognosis remains to be confirmed. More rigorous design and meticulous quality epidemiological studies are required.

High expression of long non‐coding HOX antisense transcript RNA and its clinical significance in cancer tissues: A meta‐analysis