English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  This study aimed to evaluate mutations of the epidermal growth factor receptor ( EGFR ) and  K ‐ ras  genes and their clinicopathological and prognostic features in patients with resected pathological stage  I  adenocarcinoma.    Methods  We examined 224 patients with surgically resected lung adenocarcinoma and analyzed the prognostic and predictive value of these mutations in 162 patients with pathological stage  I  adenocarcinoma.    Results  Mutations of the  EGFR  and  K ‐ ras  genes were detected in 100 (44.6%) and 19 (8.5%) of all tumors, and in 81 (50.0%) and 17 (10.5%) of the pathological stage  I  tumors, respectively.  EGFR  mutations were significantly associated with female gender, smoking habit (never smoker), and low grade. By contrast,  K ‐ ras  mutations were significantly associated with male gender, smoking habit (ever smoker), and the presence of mucinous components. No significant differences were observed in recurrence‐free or overall survival between the  EGFR ‐mutant,  K ‐ ras ‐mutant, and wild‐type groups (five‐year recurrence‐free survival 77.8% vs. 87.8% vs. 79.5%; five‐year overall survival 82.8% vs. 82.4% vs. 79.2%, respectively). Multivariate analysis showed that neither  EGFR  nor  K ‐ ras  mutation was an independent prognostic factor.    Conclusions  The present study demonstrated that pathological stage  I  adenocarcinoma harboring  EGFR  and  K ‐ ras  gene mutations have distinct clinicopathological features. The presence of these mutations alone were not prognostic factors in patients with resected pathological stage  I  adenocarcinoma.

thoracic cancer

Clinicopathological and prognostic features of surgically resected pathological stage  I  lung adenocarcinoma harboring epidermal growth factor receptor and  K ‐ ras  mutation