Open AccessExtent of visceral pleural invasion and the prognosis of surgically resected node‐negative non‐small cell lung cancer
Author(s) -
Seok Yangki,
Jeong Ji Yun,
Lee Eungbae
Publication year - 2017
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12424
Subject(s) - medicine , hazard ratio , proportional hazards model , lung cancer , multivariate analysis , oncology , retrospective cohort study , confidence interval , gastroenterology
Background Visceral pleural invasion ( VPI ) is generally considered a poor prognostic factor in non‐small cell lung cancer ( NSCLC ). VPI is defined as penetration beyond the elastic layer of visceral pleura ( PL 1), including the visceral pleural surface without the involvement of adjacent structures ( PL 2) by cancer cells. The aim of this study was to evaluate the influence of the extent of VPI on NSCLC prognosis. Methods This was a retrospective study of 90 patients with resected node‐negative NSCLC with VPI . The overall survival ( OS ) and disease‐free survival ( DFS ) rates were estimated using the K aplan– M eier m ethod. Multivariate analysis for prognostic factors was performed using a C ox proportional hazards regression model. The pattern of recurrence was also compared between PL 1 and PL 2 groups. Results Seventy‐three patients had PL 1. The three‐year OS rates for the PL 1 and PL 2 groups were 97.4% and 82.4%, respectively ( P = 0.004). The two‐year DFS rates for PL 1 and PL 2 groups were 81.0% and 76.5%, respectively ( P = 0.419). According to the multivariate analysis, PL 2 was not a significant prognostic factor for survival outcome in node‐negative NSCLC with VPI compared to PL 1 (hazard ratio for DFS 1.753, 95% confidence interval 0.582–5.284; P = 0.319). In this study, six patients in the PL 1 and one in PL 2 group developed ipsilateral pleural recurrence ( P = 1.000). Conclusion VPI extent may not influence survival outcomes in patients with surgically resected node‐negative NSCLC with VPI .