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Background  Comorbidity has a great impact on lung cancer survival. Renal function status may affect treatment decisions and drug toxicity. The survival outcome in lung cancer patients with coexisting chronic kidney disease ( CKD)  has not been fully evaluated. We hypothesized that  CKD  is an independent risk factor for mortality in patients with lung cancer.    Methods  A retrospective, propensity‐matched study of 434 patients diagnosed between  J une 2004 and  M ay 2012 was conducted.  CKD  was defined as estimated glomerular filtration rate <60 mL/minute. Lung cancer and coexisting  CKD  patients were matched 1:1 to patients with lung cancer without  CKD .    Results  Age, gender, smoking status, histology, and lung cancer stage were not statistically significantly different between the  CKD  and non‐ CKD  groups. Kaplan– M eier survival analysis demonstrated a median survival of 7.26 months (95% confidence interval [ CI]  6.06–8.46) in the  CKD  group compared with 7.82 months (95%  CI  6.33–9.30) in the non‐ CKD  group ( P  = 0.41). Lung cancer stage‐specific survival is not affected by  CKD . Although lung cancer patients with  CKD  presented with an increased risk of death of 6%, this result was not statistically significant ( hazard ratio  1.06, 95%  CI  0.93–1.22;  P  = 0.41).    Conclusion  According to our limited experience,  CKD  is not an independent risk factor for survival in lung cancer patients. Clinicians should not be discouraged to treat lung cancer patients with  CKD .

Is chronic kidney disease an adverse factor in lung cancer clinical outcome? A propensity score matching study