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Background  The lung cancer mortality rate in  X uanwei city is among the highest in  C hina and adenocarcinoma is the major histological type. Lung cancer has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons; however, the pathogenesis of lung cancer has not yet been fully elucidated.    Methods  We performed whole genome sequencing with lung adenocarcinoma and corresponding non‐tumor tissue to explore the genomic features of  X uanwei lung cancer. We used the  M olecule  A nnotation  S ystem to determine and plot alterations in genes and signaling pathways.    Results  A total of 3 428 060 and 3 416 989 single nucleotide variants were detected in tumor and normal genomes, respectively. After comparison of these two genomes, 977 high‐confidence somatic single nucleotide variants were identified. We observed a remarkably high proportion of  C · G ‐ A · T  transversions.  HECTD4 ,  RCBTB2 ,  KLF15 , and  CACNA1C  may be cancer‐related genes. Nine copy number variations increased in chromosome 5 and one in chromosome 7. The novel junctions were detected  via  clustered discordant paired ends and 1955 structural variants were discovered. Among these, we found 44 novel chromosome structural variations. In addition,  EGFR  and  CACNA1C  in the mitogen‐activated protein kinase signaling pathway were mutated or amplified in lung adenocarcinoma tumor tissue.    Conclusion  We obtained a comprehensive view of somatic alterations of  X uanwei lung adenocarcinoma. These findings provide insight into the genomic landscape in order to further learn about the progress and development of  X uanwei lung adenocarcinoma.

Whole genome sequencing analysis of lung adenocarcinoma in X uanwei, C hina