Open AccessLymph node metastasis according to primary tumor location in T 1 and T 2 stage non‐small cell lung cancer patients
Author(s) -
Xiong Jian,
Wang Rui,
Sun Yihua,
Chen Haiquan
Publication year - 2016
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12328
Subject(s) - medicine , mediastinum , stage (stratigraphy) , lymph node , mediastinal lymph node , lung cancer , lymph , metastasis , pathological , primary tumor , radiology , cancer , pathology , paleontology , biology
Background To evaluate the pattern of lymph node metastasis ( LNM ) according to primary tumor location in T 1 and T 2 stage non‐small cell lung cancer ( NSCLC ) patients. Methods The data of 1916 NSCLC patients with LNM who underwent surgery with systematic nodal resection between N ovember 2008 to D ecember 2014 were included in the study. Analyses of tumor location, pathological T stage, and nodal metastasis were performed. Results In T 1a stage patients, superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases were observed in primary tumors present in the right upper lobe ( RUL ), left upper lobe ( LUL ) and right middle lobe ( RML ), respectively. In T 1b‐stage patients, superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases were observed in the RML , LUL, and right lower lobe ( RLL ), respectively. In patients with T 2a‐stage, superior mediastinum, aortopulmonary and inferior mediastinum lymph node metastases were observed in the RUL , LUL, and RLL, respectively. However, in T2b‐stage patients, RUL , LUL and RML locations were associated with superior mediastinum, aortopulmonary, and inferior mediastinum lymph node metastases, respectively. Multivariable logistic regression showed that T stage was significantly associated with mediastinal and intrapulmonary lymph node metastases. In addition, tumor location was significantly associated with N 2 station LNM . Conclusion LNM varied according to tumor location and T ‐stage, which are independent factors influencing N 2 station LNM .