Open AccessTissue‐specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non‐small cell lung cancer
Author(s) -
Pu Qiang,
Huang Yuchuan,
Lu Yanrong,
Peng Yong,
Zhang Jie,
Feng Guanglin,
Wang Changguo,
Liu Lunxu,
Dai Ya
Publication year - 2016
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12317
Subject(s) - medicine , stage (stratigraphy) , microrna , pathology , lung cancer , lung , oncology , gene , biology , paleontology , biochemistry
In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma mi RNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue mi RNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature mi RNA s between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, mi R ‐3679‐3p, and mi R ‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and mi R ‐3613‐3p, miR‐3675‐3p, and mi R ‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma mi RNA s could be potential biomarkers of histological classification and TNM stage in NSCLC.