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In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma mi RNA  profiling preoperatively and seven days postoperatively, and cancer and normal tissue mi RNA  profiling were performed in  NSCLC  patients and matched healthy controls. There was a > twofold change for all signature mi RNA s between the  NSCLC  patients and controls, with  P  values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, mi R ‐3679‐3p, and mi R ‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and mi R ‐3613‐3p, miR‐3675‐3p, and mi R ‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma mi RNA s could be potential biomarkers of histological classification and  TNM  stage in NSCLC.

Tissue‐specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non‐small cell lung cancer