Open AccessCUG ‐binding protein 1 ( CUGBP 1) expression and prognosis of brain metastases from non‐small cell lung cancer
Author(s) -
Wang Xiaofei,
Jiao Wenjie,
Zhao Yandong,
Zhang Liangdong,
Yao Ruyong,
Wang Yongjie,
Wang Mingzhao,
Luo Yiren,
Zhao Jinpeng
Publication year - 2016
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12268
Subject(s) - medicine , immunohistochemistry , lung cancer , messenger rna , oncology , univariate analysis , cancer research , proportional hazards model , cancer , pathology , multivariate analysis , biology , gene , biochemistry
Background The brain is a frequent site of metastases from non‐small cell lung cancer ( NSCLC ). The purpose of this study was to detect the expression of CUG ‐binding protein 1 ( CUGBP 1) messenger ribonucleic acid ( mRNA ) and K i‐67 in metastasized brain tissue from NSCLC and determine the relationship between CUGBP 1 and brain metastases. Methods The expression of CUGBP 1 mRNA and K i‐67 in metastasized brain tissue from NSCLC was investigated by semiquantitative polymerase chain reaction and immunohistochemistry, respectively. The expression of CUGBP 1 and K i‐67 in metastasized brain tissue from NSCLC was related to clinical characteristics, as assessed using the chi‐square test. The prognostic significance was assessed by univariate and multivariate analyses using the C ox hazard model. Results The expression of CUGBP 1 mRNA and K i‐67 was overexpressed in metastasized brain tissue from NSCLC and was correlated with differentiation. In addition, by both univariate and multivariate survival analyses, CUGBP 1 expression, K i‐67 expression, and age were noted to be independent indicators of a shorter postsurgical survival. Conclusion The expression of CUGBP 1 is an important factor in the development of brain metastases from NSCLC .