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Background  The brain is a frequent site of metastases from non‐small cell lung cancer ( NSCLC ). The purpose of this study was to detect the expression of  CUG ‐binding protein 1 ( CUGBP 1) messenger ribonucleic acid ( mRNA ) and  K i‐67 in metastasized brain tissue from  NSCLC  and determine the relationship between  CUGBP 1 and brain metastases.    Methods  The expression of  CUGBP 1  mRNA  and  K i‐67 in metastasized brain tissue from  NSCLC  was investigated by semiquantitative polymerase chain reaction and immunohistochemistry, respectively. The expression of  CUGBP 1 and  K i‐67 in metastasized brain tissue from  NSCLC  was related to clinical characteristics, as assessed using the chi‐square test. The prognostic significance was assessed by univariate and multivariate analyses using the  C ox hazard model.    Results  The expression of  CUGBP 1  mRNA  and  K i‐67 was overexpressed in metastasized brain tissue from  NSCLC  and was correlated with differentiation. In addition, by both univariate and multivariate survival analyses,  CUGBP 1 expression,  K i‐67 expression, and age were noted to be independent indicators of a shorter postsurgical survival.    Conclusion  The expression of  CUGBP 1 is an important factor in the development of brain metastases from  NSCLC .

CUG ‐binding protein 1 ( CUGBP 1) expression and prognosis of brain metastases from non‐small cell lung cancer