Open AccessPrimary extranodal natural killer/ T ‐cell lymphoma of bronchus and lung: A case report and review of literature
Author(s) -
Chien ChuChun,
Lee HerngSheng,
Lin MinHsi,
Hsieh PinPen
Publication year - 2016
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12254
Subject(s) - medicine , pathology , lymphoma , pleural effusion , large cell , non hodgkin's lymphoma , lung , biopsy , adenocarcinoma , cancer
Primary pulmonary non‐ H odgkin's lymphoma ( NHL ) is very rare. It represents less than 1% of all NHL , and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B ‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK / T ‐cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD 3, CD 56, granzyme B , and negative for cytokeratin, CD 20 immunostains, suggesting NK / T cell lineages. In situ hybridization for E pstein‐ B arr virus encoded ribonucleic acid ( EBER ) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK / T ‐cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto‐peripheral blood stem cell transplantation.