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Background  Accumulated evidence has revealed that the dysregulation of micro ribonucleic acids (mi RNA s) may contribute to esophageal squamous cell carcinoma ( ESCC ). Mi R ‐93, which is a member of the mi RNA  cluster mi R ‐106b∼25, has been widely studied for its tumor promoting effect on different types of cancers. However, our knowledge of mi R ‐93 function in  ESCC  remains unclear.    Methods  The expression levels of mi R ‐93 in  ESCC  and the adjacent non‐tumor tissues were measured by real‐time polymerase chain reaction. Cell counting kit‐8, flow cytometry, and 5‐ethynyl‐2′‐deoxyuridine incorporation and transwell migration assays were employed to explore the effects of miR‐93 on proliferation and migration capabilities in  EC109  cells. To determine the possible target gene of mi R ‐93, cell transfection, Western blot analysis and luciferase reporter gene assays were performed.    Results  A significant upregulation of mi R ‐93 expression in  ESCC  tissues was determined, combined with a downregulation of the predicted target gene, disabled 2 ( DAB2) . The introduction of mi R ‐93 significantly promotes cell proliferation, cell cycle progression, and the metastatic capability of  EC109  cells. By cell transfection and luciferase reporter assay,  DAB2  was confirmed as a direct target of mi R ‐93. In addition, the knockdown of  DAB2  by small interfering  RNA  displayed a consentaneous phenocopy with miR‐93 overexpression in  EC109  cells.    Conclusion  Our results indicate that mi R ‐93 acts as a tumor promoter in  ESCC , and its promotion effects on  ESCC  cell proliferation and migration depend largely upon  DAB2  suppression.

Micro ribonucleic acid‐93 promotes proliferation and migration of esophageal squamous cell carcinoma by targeting disabled 2