Open AccessPrognostic value and clinicopathological significance of epithelial cadherin expression in non‐small cell lung cancer
Author(s) -
Qiu ZhiXin,
Zhao Shuang,
Li Lei,
Li WeiMin
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12227
Subject(s) - medicine , cadherin , lung cancer , expression (computer science) , value (mathematics) , lung , oncology , pathology , cancer , cell , cancer research , genetics , biology , machine learning , computer science , programming language
Background Epithelial cadherin ( E ‐cadherin), a calcium‐dependent cell‐cell adhesion molecule, as an important adhesion and signaling pathway mediator plays key roles in the maintenance of tissue integrity. However, the available results of E ‐cadherin expression and its prognostic value on non‐small cell lung cancer ( NSCLC ) remain controversial. Therefore, a meta‐analysis of published studies investigating the prognostic value of E ‐cadherin expression and its association with clinicopathological characteristics with NSCLC was performed. Methods A literature search via PubMed , EMBASE, and MEDLINE ( O vid) databases was conducted. Data from eligible studies were extracted. Statistical analysis was performed using STATA 12.0. Results A total of 2412 patients from 15 studies were included in the meta‐analysis. The results showed that the pooled hazard ratio ( HR ) for overall survival was 0.55 (95% confidence interval [ CI ]: 0.44–0.69) by univariate analysis and 0.68 (95% CI : 0.43–1.08) by multivariate analysis. In addition, the results showed a significant association between E ‐cadherin expression and the presence of lymph node metastasis (odds ratio = 0.37, 95% CI =0.05–0.69, P = 0.001). Conclusion Our study showed that positive expression of E ‐cadherin was associated with a favorable prognosis in patients with NSCLC , and might act as an inhibition factor of metastasis. However, adequately designed prospective studies are required to confirm this finding.